PDX1

Across TCGA cell cohorts, PDX1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDX1-associated genes across cancer lineages are PRAMEF14, GH1, and C1orf162. Each is linked with PDX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDX1-to-partner and partner-to-PDX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF14 grouped by PDX1-low versus PDX1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDX1→partner) and Y-score (partner→PDX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRAMEF14 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	GH1 →	+0.049	+4.906	<.001	.006	3	1
LARGE_INTESTINE	C1orf162 →	+0.325	+3.131	<.001	.008	3	1
LARGE_INTESTINE	ERLIN2 →	+0.829	+3.064	.001	.009	3	1
LARGE_INTESTINE	MTNR1A →	+0.425	+3.064	<.001	.009	3	1
LARGE_INTESTINE	CHRM1 →	+0.793	+3.241	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PRAMEF14 by PDX1 expression — OESOPHAGUS

Explore this box plot interactively →