PDSS2

Across TCGA patient cohorts, PDSS2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,673 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PDSS2-associated genes across cancer lineages are CYBRD1, LSM11, and CRTAP. Each is linked with PDSS2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PDSS2-to-partner and partner-to-PDSS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDSS2 versus CYBRD1 in BRCA, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDSS2→partner) and Y-score (partner→PDSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CYBRD1 →	-1.462	-0.428	<.001	<.001	3	5
LSCC	LSM11 →	-0.394	-0.321	<.001	<.001	3	4
BRCA	CRTAP →	-0.527	-0.364	<.001	<.001	3	4
LSCC	IAH1 →	-0.306	-0.214	<.001	<.001	3	4
UCEC	ECM2 →	-0.586	-0.341	.002	.004	3	4
UCEC	C2orf27A →	-0.657	-0.417	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,673 associations by consensus.

PDSS2 vs CYBRD1 — BRCA

Explore this scatter interactively →