PDSS2

Across TCGA patient cohorts, PDSS2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDSS2-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and EGFR_pY1068. Each is linked with PDSS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDSS2-to-partner and partner-to-PDSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PDSS2-low versus PDSS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDSS2→partner) and Y-score (partner→PDSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.600	+2.341	.020	.019	3	2
UCEC	14-3-3_beta →	-0.115	-2.794	.008	.003	3	1
UCEC	EGFR_pY1068 →	-0.270	-2.115	.013	.019	3	1
UCEC	FoxM1 →	+0.283	+2.115	.012	.019	3	1
UCEC	G6PD →	-0.286	-2.301	.043	.034	3	1
UCEC	Gab2 →	+0.422	+2.115	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-7-cleavedD198 by PDSS2 expression — UCEC

Explore this box plot interactively →