PDRG1

Across TCGA cell cohorts, PDRG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,580 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDRG1-associated GO terms across cancer lineages are IRE1-mediated unfolded protein response, Regulation of DNA replication, and Spliceosomal snRNP assembly. Each is linked with PDRG1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PDRG1-to-partner and partner-to-PDRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRE1-mediated unfolded protein response grouped by PDRG1-low versus PDRG1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDRG1→partner) and Y-score (partner→PDRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IRE1-mediated unfolded protein response →	+0.112	+0.437	<.001	.001	3	13
LIVER	Regulation of DNA replication →	+0.097	+0.753	<.001	<.001	3	11
BREAST	Spliceosomal snRNP assembly →	+0.081	+0.676	<.001	.002	3	10
SOFT_TISSUE	DNA-templated transcription initiation →	+0.056	+0.631	<.001	<.001	3	10
BLOOD_Myeloma	Sister chromatid cohesion →	+0.100	+0.827	<.001	<.001	3	10
SOFT_TISSUE	Positive regulation of mitotic cell cycle phase transition →	+0.096	+0.813	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,580 associations by consensus.

IRE1-mediated unfolded protein response by PDRG1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →