PDRG1

Across TCGA pan-cancer cohorts, PDRG1 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated PDRG1 data layer compared with 1 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher PDRG1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PDRG1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SCLC show a favorable association.

LIHC, UVM, and LGG are the cancer types where PDRG1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.585	0.780	<.001	104	view →
UVM	DFS	Quartile	All	0.246	1.000	.001	66	view →
LGG	DFS	Median	All	0.655	0.819	<.001	53	view →
KIRC	DFS	Median	II,III,IV	0.726	0.871	.011	48	view →
KICH	OS	Median	All	0.833	1.000	.013	39	view →
MESO	OS	Median	All	0.294	0.488	.004	39	view →
LUAD	DFS	Median	IV	0.843	0.240	.001	36	view →
CESC	DFS	Tertile	IV	0.092	0.579	.009	30	view →
PRAD	DFS	Median	All	0.683	0.892	<.001	30	view →
UCEC	DFS	Quartile	All	0.620	0.822	.002	26	view →
SKCM	OS	Median	All	0.296	0.496	.003	22	view →
DLBC	DFS	Median	II,III,IV	0.477	1.000	.005	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

PDRG1–LIHC (OS)

Open the LIHC breakdown →