PDPR

Across TCGA patient cohorts, PDPR mutation is significantly associated with the RNA expression of many other genes, with 2,368 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDPR-associated genes across cancer lineages are OR4A8, CFHR2, and SLC9A3P1. Each is linked with PDPR in more than 2 cancer types. Because this analysis shows association rather than direction, both PDPR-to-partner and partner-to-PDPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4A8 grouped by PDPR-low versus PDPR-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDPR→partner) and Y-score (partner→PDPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OR4A8 →	+0.065	+6.568	<.001	<.001	3	3
CESC	CFHR2 →	+0.062	+5.579	<.001	.001	3	2
CESC	SLC9A3P1 →	+0.020	+4.757	.006	.004	3	2
SKCM	KDM5C-IT1 →	+0.081	+2.660	.006	.005	3	2
LUAD	RNU105C →	+0.292	+5.327	<.001	.002	3	2
LUAD	RNA5SP141 →	+0.512	+4.612	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,368 associations by consensus.

OR4A8 by PDPR expression — COAD

Explore this box plot interactively →