PDPR

Across TCGA patient cohorts, PDPR mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDPR-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and JNK2. Each is linked with PDPR in more than 1 cancer types. Because this analysis shows association rather than direction, both PDPR-to-partner and partner-to-PDPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PDPR-low versus PDPR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDPR→partner) and Y-score (partner→PDPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.135	-2.584	.005	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.124	-1.690	.013	.042	3	1
UCEC	JNK2 →	+0.304	+2.348	<.001	.018	3	1
UCEC	Ku80 →	+0.239	+1.498	.011	.036	3	1
UCEC	MEK1 →	+0.399	+2.222	.006	.010	3	1
UCEC	p70-S6K_pT389 →	-0.201	-3.321	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

A-Raf_pS299 by PDPR expression — UCEC

Explore this box plot interactively →