PDPR

Across TCGA cell cohorts, PDPR mutation is significantly associated with the RNA expression of many other genes, with 350 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDPR-associated genes across cancer lineages are TCF23, ANKRD30BL, and CFHR4. Each is linked with PDPR in more than 2 cancer types. Because this analysis shows association rather than direction, both PDPR-to-partner and partner-to-PDPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF23 grouped by PDPR-low versus PDPR-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDPR→partner) and Y-score (partner→PDPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TCF23 →	+0.018	+3.643	<.001	.007	3	3
CNS	ANKRD30BL →	+0.245	+3.874	<.001	.006	3	2
CNS	CFHR4 →	+0.187	+3.843	<.001	.007	3	2
CNS	OR2A5 →	+0.035	+4.044	.006	.003	3	2
STOMACH	SSX2 →	+1.395	+3.700	<.001	.003	3	2
LARGE_INTESTINE	HRH3 →	+0.210	+2.546	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 350 associations by consensus.

TCF23 by PDPR expression — CNS

Explore this box plot interactively →