PDPR

Across TCGA cell cohorts, PDPR mutation is significantly associated with the mutation status of many other genes, with 2,543 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDPR-associated genes across cancer lineages are HSF1, PCDH11X, and NACA. Each is linked with PDPR in more than 4 cancer types. Because this analysis shows association rather than direction, both PDPR-to-partner and partner-to-PDPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSF1 grouped by PDPR-low versus PDPR-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDPR→partner) and Y-score (partner→PDPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HSF1 →	+4.969	+4.014	.008	.008	1	5
BREAST	PCDH11X →	+4.857	+4.297	.009	.009	1	4
SOFT_TISSUE	NACA →	+5.502	+5.502	.003	.003	1	4
LUNG_NSCLC_LUAD	SLC6A11 →	+3.851	+3.263	.005	.005	1	4
SOFT_TISSUE	NES →	+4.502	+5.066	.007	.007	1	4
SOFT_TISSUE	SNX18 →	+5.502	+5.502	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,543 associations by consensus.

HSF1 by PDPR expression — BLOOD_Lymphoma

Explore this box plot interactively →