PDPK1

Across TCGA patient cohorts, PDPK1 protein abundance is significantly associated with the RNA expression of many other genes, with 19,764 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PDPK1-associated genes across cancer lineages are NDC80, TTK, and TOP2A. Each is linked with PDPK1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PDPK1-to-partner and partner-to-PDPK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDPK1 versus NDC80 in OV, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDPK1→partner) and Y-score (partner→PDPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NDC80 →	-1.306	-0.431	<.001	<.001	3	8
OV	TTK →	-1.308	-0.463	<.001	<.001	3	6
LUAD	TOP2A →	-0.896	-0.149	<.001	.001	3	6
UCEC	TROAP →	-0.950	-0.185	.005	.001	3	6
OV	CENPE →	-0.936	-0.390	.002	.001	3	6
BRCA	CDCA4 →	-0.687	-0.264	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,764 associations by consensus.

PDPK1 vs NDC80 — OV

Explore this scatter interactively →