PDP1

Across TCGA patient cohorts, PDP1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDP1-associated genes across cancer lineages are GAPDH, PDCD4, and ATM. Each is linked with PDP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PDP1-to-partner and partner-to-PDP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PDP1-low versus PDP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDP1→partner) and Y-score (partner→PDP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.383	+1.765	.023	.011	3	3
UCEC	PDCD4 →	-0.496	-1.584	<.001	.005	3	3
UCEC	ATM →	-0.488	-2.209	<.001	.009	3	3
UCEC	14-3-3_beta →	-0.094	-2.143	.002	.002	3	2
UCEC	MEK1 →	+0.567	+2.807	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.146	-1.787	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

GAPDH by PDP1 expression — UCEC

Explore this box plot interactively →