PDP1

Across TCGA pan-cancer cohorts, PDP1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PDP1 data layer compared with 9 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher PDP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PDP1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and ACC show a favorable association.

OV, MESO, and UVM are the cancer types where PDP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	All	0.261	0.376	<.001	114	view →
MESO	DFS	Quartile	All	0.207	0.515	<.001	99	view →
UVM	DFS	Median	III,IV	0.324	0.766	<.001	91	view →
BRCA	OS	Median	All	0.515	0.641	<.001	58	view →
KIRP	OS	Median	III,IV	0.835	0.506	.004	57	view →
ACC	OS	Median	All	0.871	0.446	.002	49	view →
KIRC	OS	Tertile	All	0.730	0.521	<.001	47	view →
HNSC	OS	Median	III,IV	0.554	0.697	.002	30	view →
THYM	DFS	Tertile	All	1.000	0.545	.002	29	view →
PAAD	DFS	Quartile	All	0.168	0.433	.005	27	view →
CHOL	DFS	Quartile	All	0.792	0.116	.026	15	view →
SARC	DFS	Median	All	0.475	0.703	.001	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PDP1–OV (OS)

Open the OV breakdown →