PDLIM4

Across TCGA patient cohorts, PDLIM4 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDLIM4-associated genes across cancer lineages are EGFR_pY1068, JNK2, and MAPK_pT202_Y204. Each is linked with PDLIM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDLIM4-to-partner and partner-to-PDLIM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PDLIM4-low versus PDLIM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDLIM4→partner) and Y-score (partner→PDLIM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.292	-2.459	.016	.020	3	1
UCEC	JNK2 →	+0.204	+2.459	.033	.020	3	1
UCEC	MAPK_pT202_Y204 →	-0.512	-2.459	.024	.020	3	1
UCEC	MEK1_p_S217_S221 →	-0.332	-3.169	.011	.019	3	1
UCEC	Notch1 →	+0.233	+2.335	<.001	.018	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.677	-3.571	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by PDLIM4 expression — UCEC

Explore this box plot interactively →