PDLIM4

Across TCGA pan-cancer cohorts, PDLIM4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PDLIM4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PDLIM4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PDLIM4 is over-expressed in tumor, although a few such as BLCA and KIRC show the opposite, repressed pattern.

THCA, BLCA, and LUAD are the cancer types where PDLIM4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDLIM4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	+4.670	<.001	11	view →
BLCA	Male	III,IV	−2.137	<.001	11	view →
LUAD	All	III,IV	+1.778	<.001	8	view →
KIRC	All	II,III,IV	−0.674	<.001	8	view →
LUSC	Male	All	+1.819	<.001	7	view →
BRCA	Female	All	−1.540	<.001	6	view →
UCEC	All	II,III,IV	−1.522	<.001	6	view →
STAD	Female	All	−1.551	.004	4	view →
LIHC	All	II,III,IV	+0.431	.004	4	view →
CHOL	All	All	+2.308	.001	3	view →
HNSC	Male	All	+0.661	.009	3	view →
ESCA	All	II,III,IV	−1.279	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PDLIM4–THCA

Open the THCA breakdown →