PDK3

Across TCGA patient cohorts, PDK3 mutation is significantly associated with the RNA expression of many other genes, with 4,216 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDK3-associated genes across cancer lineages are RNU1-17P, MIR920, and KIAA1143P2. Each is linked with PDK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDK3-to-partner and partner-to-PDK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by PDK3-low versus PDK3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDK3→partner) and Y-score (partner→PDK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-17P →	+0.374	+5.103	<.001	.008	3	2
LUSC	MIR920 →	+0.635	+3.394	<.001	.007	3	2
CESC	KIAA1143P2 →	+0.155	+5.812	<.001	.003	3	2
UCEC	RNU6-42P →	+0.666	+1.929	<.001	<.001	3	2
HNSC	RN7SL291P →	+0.151	+5.368	.006	.005	3	2
BRCA	RNU6-1124P →	+0.259	+9.057	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,216 associations by consensus.

RNU1-17P by PDK3 expression — CESC

Explore this box plot interactively →