PDILT

Across TCGA cell cohorts, PDILT mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PDILT-associated genes across cancer lineages are OTC, NPBWR2, and OOSP4A. Each is linked with PDILT in more than 1 cancer types. Because this analysis shows association rather than direction, both PDILT-to-partner and partner-to-PDILT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTC grouped by PDILT-low versus PDILT-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDILT→partner) and Y-score (partner→PDILT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OTC →	+0.064	+3.772	<.001	.003	3	1
BLOOD_Lymphoma	NPBWR2 →	+0.145	+3.933	<.001	.002	3	1
BLOOD_Lymphoma	OOSP4A →	+0.029	+3.584	<.001	.004	3	1
BLOOD_Lymphoma	RAD51AP2 →	+0.146	+3.726	<.001	.004	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OTC by PDILT expression — SKIN

Explore this box plot interactively →