PDIK1L

Across TCGA patient cohorts, PDIK1L mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDIK1L-associated genes across cancer lineages are JNK_pT183_Y185, 14-3-3_beta, and EGFR_pY1068. Each is linked with PDIK1L in more than 1 cancer types. Because this analysis shows association rather than direction, both PDIK1L-to-partner and partner-to-PDIK1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by PDIK1L-low versus PDIK1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDIK1L→partner) and Y-score (partner→PDIK1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.171	-2.000	.005	.030	3	2
UCEC	14-3-3_beta →	-0.100	-2.432	.006	.018	3	1
UCEC	EGFR_pY1068 →	-0.278	-2.247	.002	.001	3	1
UCEC	EGFR →	-0.163	-2.321	.005	.034	3	1
UCEC	eIF4E →	+0.234	+3.472	.002	.002	3	1
UCEC	A-Raf_pS299 →	-0.154	-3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

JNK_pT183_Y185 by PDIK1L expression — UCEC

Explore this box plot interactively →