PDIK1L

Across TCGA pan-cancer cohorts, PDIK1L RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PDIK1L data layer compared with 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PDIK1L RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PDIK1L expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, HNSC, and KIRC are the cancer types where PDIK1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.622	0.361	<.001	97	view →
HNSC	DFS	Quartile	All	0.793	0.626	<.001	90	view →
KIRC	OS	Tertile	All	0.732	0.544	<.001	65	view →
LGG	DFS	Median	All	0.666	0.817	<.001	47	view →
SKCM	DFS	Tertile	All	0.715	0.523	<.001	38	view →
COAD	OS	Median	II,III,IV	0.851	0.720	.002	33	view →
LIHC	DFS	Median	All	0.474	0.608	.002	31	view →
GBM	DFS	Quartile	All	0.450	0.144	<.001	18	view →
UCEC	OS	Median	III,IV	0.881	0.776	.003	18	view →
READ	OS	Tertile	IV	0.924	0.490	.010	18	view →
BRCA	DFS	Median	III,IV	0.938	0.813	.001	16	view →
MESO	OS	Median	All	0.278	0.688	.014	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PDIK1L–LUAD (DFS)

Open the LUAD breakdown →