PDIA6

Across TCGA pan-cancer cohorts, PDIA6 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PDIA6 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PDIA6 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDIA6 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and LGG are the cancer types where PDIA6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.122	0.710	.001	24	view →
UCEC	DFS	Median	III,IV	1.000	0.537	.026	20	view →
LGG	OS	Median	All	0.195	0.889	<.001	10	view →
BLCA	DFS	Median	All	0.184	0.597	.027	6	view →
ESCA	DFS	Median	All	0.146	0.533	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PDIA6–HNSC (DFS)

Open the HNSC breakdown →