PDIA6

Across TCGA patient cohorts, PDIA6 protein abundance is significantly associated with the RNA expression of many other genes, with 18,979 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PDIA6-associated genes across cancer lineages are SH3GLB2, C9orf85, and LMOD1. Each is linked with PDIA6 in more than 5 cancer types. Because this analysis shows association rather than direction, both PDIA6-to-partner and partner-to-PDIA6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDIA6 versus SH3GLB2 in OV, with a Pearson correlation of -0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDIA6→partner) and Y-score (partner→PDIA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SH3GLB2 →	-0.912	-0.519	<.001	<.001	3	6
LSCC	C9orf85 →	-0.530	-0.320	<.001	<.001	3	6
CCRCC	LMOD1 →	-1.083	-0.315	<.001	.001	3	6
GBM	TTLL11 →	-0.565	-0.411	<.001	<.001	3	6
BRCA	SECISBP2 →	-0.580	-0.354	<.001	<.001	3	6
OV	ZNF510 →	-0.557	-0.453	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,979 associations by consensus.

PDIA6 vs SH3GLB2 — OV

Explore this scatter interactively →