PDIA6

Across TCGA cell cohorts, PDIA6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,730 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PDIA6-associated GO terms across cancer lineages are Glycoprotein biosynthetic process, Protein O-linked glycosylation, and Attachment of GPI anchor to protein. Each is linked with PDIA6 in more than 17 cancer types. Because this analysis shows association rather than direction, both PDIA6-to-partner and partner-to-PDIA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycoprotein biosynthetic process grouped by PDIA6-low versus PDIA6-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDIA6→partner) and Y-score (partner→PDIA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Glycoprotein biosynthetic process →	+0.052	+0.815	<.001	.001	3	18
SKIN	Protein O-linked glycosylation →	+0.060	+1.025	<.001	<.001	3	12
BONE	Attachment of GPI anchor to protein →	+0.134	+0.777	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Protein N-linked glycosylation →	+0.091	+0.945	<.001	.002	3	11
BREAST	Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway →	+0.105	+0.663	.001	<.001	3	11
LUNG_SCLC	'de novo' post-translational protein folding →	+0.101	+0.635	.001	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,730 associations by consensus.

Glycoprotein biosynthetic process by PDIA6 expression — OESOPHAGUS

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