PDIA6

Across TCGA cell cohorts, PDIA6 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDIA6-associated genes across cancer lineages are FHL5, MS4A4A, and TAFA1. Each is linked with PDIA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDIA6-to-partner and partner-to-PDIA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FHL5 grouped by PDIA6-low versus PDIA6-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDIA6→partner) and Y-score (partner→PDIA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FHL5 →	+0.006	+4.906	<.001	.006	3	1
LARGE_INTESTINE	MS4A4A →	+0.182	+3.000	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.236	+4.009	.001	<.001	3	1
LARGE_INTESTINE	BPIFA1 →	+0.114	+3.103	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

FHL5 by PDIA6 expression — OESOPHAGUS

Explore this box plot interactively →