PDHX

Across TCGA patient cohorts, PDHX mutation is significantly associated with the RNA expression of many other genes, with 4,102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDHX-associated genes across cancer lineages are RN7SL722P, RNU1-6P, and RNU6-24P. Each is linked with PDHX in more than 1 cancer types. Because this analysis shows association rather than direction, both PDHX-to-partner and partner-to-PDHX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL722P grouped by PDHX-low versus PDHX-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDHX→partner) and Y-score (partner→PDHX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL722P →	+0.126	+7.471	<.001	.008	3	2
CESC	RNU1-6P →	+0.388	+5.969	<.001	.002	3	2
BRCA	RNU6-24P →	+0.412	+5.148	<.001	.008	3	2
BRCA	PRRC2CP1 →	+0.325	+8.467	<.001	<.001	3	2
BRCA	MRPS17P3 →	+0.138	+5.409	<.001	.005	3	2
SKCM	ACTR3BP1 →	+0.028	+5.469	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,102 associations by consensus.

RN7SL722P by PDHX expression — BRCA

Explore this box plot interactively →