PDHB

Across TCGA patient cohorts, PDHB mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDHB-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and mTOR_pS2448. Each is linked with PDHB in more than 1 cancer types. Because this analysis shows association rather than direction, both PDHB-to-partner and partner-to-PDHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by PDHB-low versus PDHB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDHB→partner) and Y-score (partner→PDHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.185	-2.584	.012	.010	3	1
UCEC	MEK1 →	+0.395	+2.459	.013	.019	3	1
UCEC	mTOR_pS2448 →	-0.169	-3.446	.009	.005	3	1
UCEC	Notch1 →	+0.176	+2.469	.004	.010	3	1
UCEC	p27_pT198 →	+0.103	+2.999	.027	.035	3	1
UCEC	P-Cadherin →	-0.152	-3.169	.015	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

JNK_pT183_Y185 by PDHB expression — UCEC

Explore this box plot interactively →