PDHB

Across TCGA cell cohorts, PDHB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,109 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PDHB-associated GO terms across cancer lineages are Mitotic spindle assembly, Mitochondrial mRNA catabolic process, and Regulation of mitochondrial mRNA stability. Each is linked with PDHB in more than 12 cancer types. Because this analysis shows association rather than direction, both PDHB-to-partner and partner-to-PDHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic spindle assembly grouped by PDHB-low versus PDHB-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDHB→partner) and Y-score (partner→PDHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Mitotic spindle assembly →	+0.080	+0.651	<.001	.002	3	13
LIVER	Mitochondrial mRNA catabolic process →	+0.142	+0.740	<.001	<.001	3	12
LIVER	Regulation of mitochondrial mRNA stability →	+0.134	+0.592	<.001	.004	2	13
BLOOD_Lymphoma	Pyruvate decarboxylation to acetyl-CoA →	+0.112	+0.679	<.001	.001	3	12
URINARY_TRACT	IMP biosynthetic process →	+0.193	+0.974	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.129	+1.065	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,109 associations by consensus.

Mitotic spindle assembly by PDHB expression — OVARY

Explore this box plot interactively →