PDHA2

Across TCGA patient cohorts, PDHA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,681 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PDHA2-associated GO terms across cancer lineages are RNA 3'-end processing, Signal transduction in response to DNA damage, and Amino acid activation. Each is linked with PDHA2 in more than 7 cancer types. Because this analysis shows association rather than direction, both PDHA2-to-partner and partner-to-PDHA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA 3'-end processing grouped by PDHA2-low versus PDHA2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDHA2→partner) and Y-score (partner→PDHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNA 3'-end processing →	+0.036	+0.069	<.001	.002	3	7
STAD	Signal transduction in response to DNA damage →	+0.037	+0.062	<.001	.002	3	7
STAD	Amino acid activation →	+0.053	+0.085	<.001	.001	3	7
STAD	Mitotic DNA integrity checkpoint signaling →	+0.031	+0.042	<.001	.005	3	7
STAD	Mitotic G2/M transition checkpoint →	+0.049	+0.079	<.001	.006	3	7
STAD	Positive regulation of post-translational protein modification →	+0.056	+0.082	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,681 associations by consensus.

RNA 3'-end processing by PDHA2 expression — STAD

Explore this box plot interactively →