PDHA2

Across TCGA pan-cancer cohorts, PDHA2 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated PDHA2 data layer compared with 9 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher PDHA2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PDHA2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRP show a favorable association.

STAD, SKCM, and READ are the cancer types where PDHA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Quartile	III,IV	0.449	0.680	<.001	68	view →
SKCM	OS	Tertile	All	0.969	0.757	<.001	66	view →
READ	DFS	Tertile	IV	0.184	0.691	<.001	51	view →
KICH	DFS	Tertile	All	0.521	0.971	<.001	45	view →
MESO	OS	Tertile	All	0.244	0.575	.001	45	view →
BRCA	DFS	Tertile	All	0.140	1.000	.001	36	view →
KIRP	DFS	Tertile	III,IV	1.000	0.529	.015	36	view →
LIHC	DFS	Tertile	All	0.380	0.584	.001	33	view →
LUAD	DFS	Tertile	IV	0.405	0.755	.017	18	view →
THCA	DFS	Tertile	All	0.972	0.810	.029	12	view →
ACC	OS	Tertile	III,IV	0.189	0.764	.004	9	view →
CHOL	DFS	Tertile	All	0.093	0.434	.046	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

PDHA2–STAD (OS)

Open the STAD breakdown →