PDHA2

Across TCGA patient cohorts, PDHA2 mutation is significantly associated with the RNA expression of many other genes, with 4,631 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDHA2-associated genes across cancer lineages are CBX1, MCM10, and TOM1L1. Each is linked with PDHA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PDHA2-to-partner and partner-to-PDHA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBX1 grouped by PDHA2-low versus PDHA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDHA2→partner) and Y-score (partner→PDHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CBX1 →	+0.542	+2.818	.003	.001	3	4
UCEC	MCM10 →	+0.965	+2.938	<.001	<.001	3	4
UCEC	TOM1L1 →	+0.510	+2.338	.006	.003	3	4
UCEC	LIN7C →	+0.462	+2.502	.005	.009	3	3
UCEC	PGAP2 →	+0.430	+3.016	<.001	<.001	3	3
UCEC	FADS1 →	+0.897	+2.459	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,631 associations by consensus.

CBX1 by PDHA2 expression — UCEC

Explore this box plot interactively →