PDHA2

Across TCGA patient cohorts, PDHA2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDHA2-associated genes across cancer lineages are FASN, PDCD4, and Caspase-7-cleavedD198. Each is linked with PDHA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PDHA2-to-partner and partner-to-PDHA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PDHA2-low versus PDHA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDHA2→partner) and Y-score (partner→PDHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.319	+1.765	.031	.014	3	4
UCEC	PDCD4 →	-0.423	-1.415	.016	.046	3	3
COAD	Caspase-7-cleavedD198 →	+0.817	+3.186	.013	.009	3	3
STAD	beta-Catenin →	+0.793	+3.169	.026	.019	3	2
UCEC	Chk2_pT68 →	-0.151	-1.990	.030	.030	3	2
UCEC	Ku80 →	+0.219	+1.428	.013	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

FASN by PDHA2 expression — UCEC

Explore this box plot interactively →