PDHA2

Across TCGA cell cohorts, PDHA2 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDHA2-associated genes across cancer lineages are PF4V1, TRIM43B, and OR6F1. Each is linked with PDHA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDHA2-to-partner and partner-to-PDHA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PF4V1 grouped by PDHA2-low versus PDHA2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDHA2→partner) and Y-score (partner→PDHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PF4V1 →	+0.665	+3.215	.002	.007	3	1
LUNG_NSCLC_LUAD	TRIM43B →	+0.030	+3.787	<.001	.004	3	1
LUNG_SCLC	OR6F1 →	+0.077	+4.817	<.001	.001	3	1
LUNG_SCLC	OR4F4 →	+0.012	+4.643	<.001	.004	3	1
LUNG_SCLC	OR52E8 →	+0.040	+4.643	<.001	.004	3	1
LUNG_SCLC	TRIML1 →	+0.130	+4.269	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PF4V1 by PDHA2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →