PDGFRL

Across TCGA cell cohorts, PDGFRL mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible PDGFRL-associated genes across cancer lineages are GNG8, CNGA2, and OR5AU1. Each is linked with PDGFRL in more than 1 cancer types. Because this analysis shows association rather than direction, both PDGFRL-to-partner and partner-to-PDGFRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNG8 grouped by PDGFRL-low versus PDGFRL-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFRL→partner) and Y-score (partner→PDGFRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GNG8 →	+0.268	+4.887	.001	.009	3	1
LUNG_NSCLC_LUAD	CNGA2 →	+0.036	+4.887	<.001	.009	3	1
STOMACH	OR5AU1 →	+0.027	+4.285	<.001	.007	3	1
STOMACH	DEFB132 →	+0.084	+4.285	<.001	.007	3	1
STOMACH	PAGE3 →	+0.092	+4.285	<.001	.007	3	1
SKIN	RTL4 →	+0.006	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

GNG8 by PDGFRL expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →