PDGFRB

Across TCGA cell cohorts, PDGFRB mutation is significantly associated with the RNA expression of many other genes, with 116 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDGFRB-associated genes across cancer lineages are CPXCR1, OR2J3, and OR2L13. Each is linked with PDGFRB in more than 1 cancer types. Because this analysis shows association rather than direction, both PDGFRB-to-partner and partner-to-PDGFRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPXCR1 grouped by PDGFRB-low versus PDGFRB-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFRB→partner) and Y-score (partner→PDGFRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CPXCR1 →	+0.108	+3.614	<.001	.002	3	2
BREAST	OR2J3 →	+0.055	+4.035	<.001	.003	3	2
BLOOD_Leukemia	OR2L13 →	+0.288	+3.339	<.001	.009	3	2
BLOOD_Leukemia	CLEC9A →	+2.487	+3.392	<.001	.007	3	2
LUNG_NSCLC_LUAD	ASPA →	+0.374	+2.658	.002	.004	3	2
SOFT_TISSUE	OR4X2 →	+0.013	+4.369	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 116 associations by consensus.

CPXCR1 by PDGFRB expression — BREAST

Explore this box plot interactively →