PDGFRA

Across TCGA patient cohorts, PDGFRA mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDGFRA-associated genes across cancer lineages are Cyclin-B1, Cyclin-E2, and p38-MAPK_pT180_Y182. Each is linked with PDGFRA in more than 6 cancer types. Because this analysis shows association rather than direction, both PDGFRA-to-partner and partner-to-PDGFRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PDGFRA-low versus PDGFRA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFRA→partner) and Y-score (partner→PDGFRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.513	+2.662	<.001	<.001	3	7
STAD	Cyclin-E2 →	+0.208	+3.021	<.001	.017	3	5
LUAD	p38-MAPK_pT180_Y182 →	-0.261	-2.000	.039	.027	3	4
STAD	PKC-delta_pS664 →	-0.128	-2.984	.035	.034	3	3
BLCA	Smad1 →	+0.184	+2.824	.009	.034	3	3
UCEC	GAPDH →	+0.329	+1.514	.019	.012	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Cyclin-B1 by PDGFRA expression — UCEC

Explore this box plot interactively →