PDGFD

Across TCGA patient cohorts, PDGFD mutation is significantly associated with the RNA expression of many other genes, with 3,948 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDGFD-associated genes across cancer lineages are ICMT, CYP4F27P, and MTA2. Each is linked with PDGFD in more than 2 cancer types. Because this analysis shows association rather than direction, both PDGFD-to-partner and partner-to-PDGFD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ICMT grouped by PDGFD-low versus PDGFD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFD→partner) and Y-score (partner→PDGFD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ICMT →	+0.512	+2.413	<.001	<.001	3	3
LUAD	CYP4F27P →	+0.337	+3.514	<.001	.005	3	3
UCEC	MTA2 →	+0.424	+2.064	<.001	.001	3	3
COAD	TRABD →	+0.669	+3.239	<.001	.008	3	3
UCEC	GNB1 →	+0.429	+3.906	<.001	<.001	3	3
UCEC	PES1 →	+0.434	+2.000	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,948 associations by consensus.

ICMT by PDGFD expression — UCEC

Explore this box plot interactively →