PDGFC

Across TCGA patient cohorts, PDGFC protein abundance is significantly associated with the RNA expression of many other genes, with 4,242 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PDGFC-associated genes across cancer lineages are ITGA11, ISM1, and LOXL1. Each is linked with PDGFC in more than 5 cancer types. Because this analysis shows association rather than direction, both PDGFC-to-partner and partner-to-PDGFC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDGFC versus ITGA11 in BRCA, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFC→partner) and Y-score (partner→PDGFC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITGA11 →	+1.201	+0.410	<.001	<.001	3	6
BRCA	ISM1 →	+1.170	+0.570	<.001	<.001	3	5
OV	LOXL1 →	+1.114	+0.593	<.001	.001	3	5
OV	POGLUT2 →	+0.785	+0.647	.005	.009	3	5
HNSC	TRPC1 →	+0.954	+0.709	.003	.002	3	5
HNSC	SPOCK1 →	+1.893	+0.800	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,242 associations by consensus.

PDGFC vs ITGA11 — BRCA

Explore this scatter interactively →