Across TCGA cell cohorts, PDGFA mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PDGFA-associated genes across cancer lineages are C8B, OR13C9, and SCN10A. Each is linked with PDGFA in more than 1 cancer types. Because this analysis shows association rather than direction, both PDGFA-to-partner and partner-to-PDGFA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDGFA→partner) and Y-score (partner→PDGFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C8B →	+0.063	+4.467	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR13C9 →	+0.012	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	SCN10A →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	LCE2C →	+0.029	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	GLT6D1 →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	C18orf63 →	+0.031	+4.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

PDGFA survival (RNA) · tumor vs normal (RNA) · all PDGFA data types