PDE9A

Across TCGA patient cohorts, PDE9A protein abundance is significantly associated with the RNA expression of many other genes, with 4,976 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PDE9A-associated genes across cancer lineages are STK26, PDE9A-AS1, and PRMT5. Each is linked with PDE9A in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE9A-to-partner and partner-to-PDE9A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE9A versus STK26 in UCEC, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE9A→partner) and Y-score (partner→PDE9A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STK26 →	-1.513	-0.742	.009	.002	3	2
UCEC	PDE9A-AS1 →	+0.904	+0.598	.002	.009	2	3
CCRCC	PRMT5 →	+0.407	+0.461	.003	.002	3	2
GBM	AP4S1 →	+0.340	+0.585	.003	.003	3	2
CCRCC	TIMM9 →	+0.395	+0.515	.006	.001	3	2
GBM	ZC3H14 →	+0.295	+0.515	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,976 associations by consensus.

PDE9A vs STK26 — UCEC

Explore this scatter interactively →