PDE9A

Across TCGA patient cohorts, PDE9A mutation is significantly associated with the RNA expression of many other genes, with 2,893 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE9A-associated genes across cancer lineages are WDHD1, PGAM4, and H2AZ1. Each is linked with PDE9A in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE9A-to-partner and partner-to-PDE9A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDHD1 grouped by PDE9A-low versus PDE9A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE9A→partner) and Y-score (partner→PDE9A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	WDHD1 →	+0.713	+3.499	<.001	.002	3	3
COAD	PGAM4 →	+0.380	+3.486	<.001	.002	3	3
UCEC	H2AZ1 →	+0.704	+2.732	<.001	<.001	3	3
UCEC	UTP15 →	+0.463	+2.671	<.001	<.001	3	3
UCEC	GFM2 →	+0.529	+1.716	<.001	.004	3	3
UCEC	CENPN →	+0.694	+2.343	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,893 associations by consensus.

WDHD1 by PDE9A expression — COAD

Explore this box plot interactively →