PDE9A

Across TCGA cell cohorts, PDE9A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,590 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PDE9A-associated GO terms across cancer lineages are Negative regulation of mRNA metabolic process, CGMP catabolic process, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with PDE9A in more than 10 cancer types. Because this analysis shows association rather than direction, both PDE9A-to-partner and partner-to-PDE9A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA metabolic process grouped by PDE9A-low versus PDE9A-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE9A→partner) and Y-score (partner→PDE9A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of mRNA metabolic process →	+0.084	+2.529	<.001	<.001	3	11
PANCREAS	CGMP catabolic process →	+1.099	+1.529	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.096	+1.733	.003	<.001	3	9
SOFT_TISSUE	Negative regulation of mRNA catabolic process →	+0.066	+1.328	<.001	<.001	3	9
BREAST	ATP synthesis coupled electron transport →	+0.088	+1.255	<.001	.004	3	8
BREAST	Mitochondrial ATP synthesis coupled electron transport →	+0.088	+1.255	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,590 associations by consensus.

Negative regulation of mRNA metabolic process by PDE9A expression — LIVER

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