PDE8A

Across TCGA patient cohorts, PDE8A RNA expression is significantly associated with the protein abundance of many other proteins, with 7,451 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PDE8A-associated proteins across cancer lineages are PDE8A_S457, PTPN1, and RCN2. Each is linked with PDE8A in more than 6 cancer types. Because this analysis shows association rather than direction, both PDE8A-to-partner and partner-to-PDE8A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PDE8A versus PDE8A_S457 in HNSC, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE8A→partner) and Y-score (partner→PDE8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PDE8A_S457 →	+0.584	+0.565	<.001	<.001	3	7
CCRCC	PTPN1 →	-0.431	-0.571	<.001	<.001	3	4
LSCC	RCN2 →	+0.603	+0.536	<.001	<.001	3	4
LSCC	IGF1R →	+0.628	+0.317	<.001	.008	3	4
BRCA	ROCK2 →	+0.230	+0.533	.002	<.001	3	4
BRCA	RSU1 →	+0.309	+0.446	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,451 associations by consensus.

PDE8A vs PDE8A_S457 — HNSC

Explore this scatter interactively →