PDE8A

Across TCGA cell cohorts, PDE8A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,401 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDE8A-associated GO terms across cancer lineages are Microtubule nucleation, Microtubule polymerization, and CAMP catabolic process. Each is linked with PDE8A in more than 11 cancer types. Because this analysis shows association rather than direction, both PDE8A-to-partner and partner-to-PDE8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule nucleation grouped by PDE8A-low versus PDE8A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE8A→partner) and Y-score (partner→PDE8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Microtubule nucleation →	+0.118	+0.925	<.001	<.001	3	11
BONE	Microtubule polymerization →	+0.112	+0.938	<.001	<.001	3	11
KIDNEY	CAMP catabolic process →	+1.488	+0.861	<.001	<.001	2	12
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.122	+0.804	.006	.009	3	11
UPPER_AERODIGESTIVE_TRACT	Response to epidermal growth factor →	+0.107	+0.960	.004	<.001	3	10
LUNG_SCLC	Cellular response to epidermal growth factor stimulus →	+0.104	+0.803	.001	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,401 associations by consensus.

Microtubule nucleation by PDE8A expression — BONE

Explore this box plot interactively →