PDE6H

Across TCGA patient cohorts, PDE6H mutation is significantly associated with the RNA expression of many other genes, with 361 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible PDE6H-associated genes across cancer lineages are SNORD114-18, RNA5SP30, and LINC02353. Each is linked with PDE6H in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE6H-to-partner and partner-to-PDE6H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD114-18 grouped by PDE6H-low versus PDE6H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6H→partner) and Y-score (partner→PDE6H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD114-18 →	+0.427	+3.077	.002	.009	3	3
SKCM	RNA5SP30 →	+0.455	+5.224	<.001	.007	3	2
SKCM	LINC02353 →	+0.214	+5.037	<.001	.009	3	2
LUAD	RNA5SP388 →	+0.377	+7.930	<.001	.008	3	2
LUAD	SNORD115-2 →	+0.501	+7.930	<.001	.008	3	2
LUAD	RNU1-130P →	+0.298	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 361 associations by consensus.

SNORD114-18 by PDE6H expression — UCEC

Explore this box plot interactively →