PDE6H

Across TCGA patient cohorts, PDE6H mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE6H-associated genes across cancer lineages are VHL, VEGFR2, and MEK1. Each is linked with PDE6H in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE6H-to-partner and partner-to-PDE6H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by PDE6H-low versus PDE6H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6H→partner) and Y-score (partner→PDE6H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.809	-3.000	.039	.037	3	1
UCEC	VEGFR2 →	+0.394	+3.013	.022	.019	2	1
UCEC	MEK1 →	+0.559	+3.000	.008	.037	1	1
UCEC	MYH11 →	+1.488	+3.000	.025	.037	1	1
UCEC	p21 →	+0.269	+3.000	.015	.037	1	1
UCEC	Cyclin-B1 →	+0.761	+3.000	.019	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

VHL by PDE6H expression — UCEC

Explore this box plot interactively →