Across TCGA patient cohorts, PDE6G RNA expression is significantly associated with the protein abundance of many other proteins, with 9,112 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PDE6G-associated proteins across cancer lineages are WDFY4, DOK2, and ARHGAP30. Each is linked with PDE6G in more than 8 cancer types. Because this analysis shows association rather than direction, both PDE6G-to-partner and partner-to-PDE6G results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6G→partner) and Y-score (partner→PDE6G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDFY4 →	+0.482	+0.616	<.001	<.001	3	9
GBM	DOK2 →	+0.621	+0.325	<.001	<.001	3	9
UCEC	ARHGAP30 →	+0.481	+0.620	.001	.002	3	9
BRCA	SASH3 →	+0.487	+0.607	<.001	<.001	3	8
GBM	WAS →	+0.541	+0.504	<.001	<.001	3	8
HNSC	EVL →	+0.594	+0.455	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,112 associations by consensus.

Exploration

PDE6G survival (RNA) · tumor vs normal (RNA) · all PDE6G data types