PDE6D

Across TCGA pan-cancer cohorts, PDE6D mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PDE6D data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PDE6D mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PDE6D expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

UCEC, GBM, and LSCC are the cancer types where PDE6D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.620	1.000	.011	20	view →
GBM	DFS	Tertile	All	0.932	0.698	<.001	18	view →
LSCC	DFS	Median	II,III,IV	0.533	0.828	.015	7	view →
COAD	DFS	Quartile	All	0.815	1.000	.047	6	view →
CCRCC	OS	Tertile	III,IV	0.978	0.067	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PDE6D–UCEC (OS)

Open the UCEC breakdown →