PDE6D

Across TCGA pan-cancer cohorts, PDE6D RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PDE6D’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PDE6D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PDE6D is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LUAD, and LIHC are the cancer types where PDE6D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDE6D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.713	<.001	12	view →
LUAD	Male	II,III,IV	+0.438	<.001	11	view →
LIHC	Female	II,III,IV	+0.953	<.001	9	view →
THCA	Male	II,III,IV	−0.487	<.001	9	view →
KICH	Female	II,III,IV	−1.582	<.001	8	view →
STAD	All	II,III,IV	+0.573	.001	7	view →
KIRP	All	II,III,IV	+0.459	.013	6	view →
BRCA	All	III,IV	+0.456	<.001	6	view →
CHOL	Female	All	+1.996	<.001	5	view →
ESCA	All	All	+0.850	<.001	5	view →
COAD	All	II,III,IV	+0.217	.014	3	view →
LUSC	All	All	+0.311	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PDE6D–HNSC

Open the HNSC breakdown →