PDE6D

Across TCGA patient cohorts, PDE6D mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE6D-associated genes across cancer lineages are PCNA, S6_pS235_S236, and ASNS. Each is linked with PDE6D in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE6D-to-partner and partner-to-PDE6D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PDE6D-low versus PDE6D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6D→partner) and Y-score (partner→PDE6D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.317	+3.169	.007	.020	3	1
UCEC	S6_pS235_S236 →	+0.473	+3.169	.046	.020	3	1
UCEC	ASNS →	+0.553	+2.999	.005	.035	3	1
UCEC	MEK1 →	+0.590	+3.169	.003	.020	2	1
UCEC	Caspase-8 →	-0.291	-3.169	.035	.020	2	1
UCEC	mTOR_pS2448 →	-0.207	-3.169	.011	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PCNA by PDE6D expression — UCEC

Explore this box plot interactively →