PDE6D

Across TCGA cell cohorts, PDE6D RNA expression is significantly associated with the go_rna of many other GO terms, with 3,431 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDE6D-associated GO terms across cancer lineages are D-amino acid metabolic process, Protein-RNA covalent cross-linking repair, and Regulation of DNA damage checkpoint. Each is linked with PDE6D in more than 8 cancer types. Because this analysis shows association rather than direction, both PDE6D-to-partner and partner-to-PDE6D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, D-amino acid metabolic process grouped by PDE6D-low versus PDE6D-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6D→partner) and Y-score (partner→PDE6D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	D-amino acid metabolic process →	+1.090	+0.489	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Protein-RNA covalent cross-linking repair →	+0.122	+1.081	.004	.001	3	9
BLOOD_Leukemia	Regulation of DNA damage checkpoint →	+0.062	+0.571	<.001	<.001	3	9
CNS	Negative regulation of hydrogen peroxide metabolic process →	+0.129	+0.417	.003	.005	3	8
LUNG_NSCLC_LUAD	Otolith mineralization →	+0.096	+0.736	<.001	<.001	3	8
LIVER	Cell division →	+0.080	+1.196	.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,431 associations by consensus.

D-amino acid metabolic process by PDE6D expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →