PDE6C

Across TCGA patient cohorts, PDE6C mutation is significantly associated with the RNA expression of many other genes, with 4,415 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE6C-associated genes across cancer lineages are VENTXP3, RNA5SP457, and RNU6-1318P. Each is linked with PDE6C in more than 2 cancer types. Because this analysis shows association rather than direction, both PDE6C-to-partner and partner-to-PDE6C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VENTXP3 grouped by PDE6C-low versus PDE6C-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE6C→partner) and Y-score (partner→PDE6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VENTXP3 →	+0.035	+4.800	.004	<.001	3	3
BLCA	RNA5SP457 →	+0.455	+4.758	<.001	.003	3	3
BLCA	RNU6-1318P →	+0.253	+4.588	.003	.008	3	3
BRCA	MIR449B →	+0.633	+4.639	<.001	.005	3	3
UCEC	SRXN1 →	+0.432	+1.787	<.001	.007	3	3
LUSC	TRAJ47 →	+1.062	+3.773	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,415 associations by consensus.

VENTXP3 by PDE6C expression — BRCA

Explore this box plot interactively →