PDE6C

Across TCGA pan-cancer cohorts, PDE6C RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PDE6C data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher PDE6C RNA is associated with better overall survival. In most high-consensus cancer types, elevated PDE6C expression acts as an unfavorable survival marker, although some lineages such as BRCA and LGG show a favorable association.

BRCA, ACC, and KIRC are the cancer types where PDE6C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.714	0.371	<.001	82	view →
ACC	DFS	Tertile	All	0.354	0.842	<.001	77	view →
KIRC	DFS	Median	All	0.509	0.702	<.001	64	view →
UVM	DFS	Quartile	All	0.234	1.000	.002	63	view →
LGG	OS	Median	All	0.881	0.742	<.001	28	view →
PRAD	DFS	Median	All	0.833	0.923	<.001	26	view →
BLCA	OS	Quartile	All	0.723	0.541	.007	23	view →
SKCM	OS	Quartile	III,IV	0.600	0.304	.001	23	view →
MESO	OS	Tertile	III,IV	0.578	0.311	.011	23	view →
PAAD	OS	Median	All	0.613	0.323	.009	12	view →
COAD	DFS	Quartile	All	0.543	0.769	.006	11	view →
READ	DFS	Quartile	IV	0.451	1.000	.009	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PDE6C–BRCA (OS)

Open the BRCA breakdown →